The winger, signed from Hereford United in the summer, has been a revelation for the struggling Stags this season.
“Its bad news for us,” manager Paul Cox told the official website. “We’re just finding out if [Sam] needs a minor operation. He’s damaged an ankle ligament and a bit of it has come away from the bone"
Meanwhile striker Ben Hutchinson has suffered an hamstring tear which could rule him out for a month.
Mansfield face Accrington Stanely at the weekend, desperate for a win to halt their alarming slide down the table.