In what wil be a repeat of the two sides meeting at the same stage last season, when a contraversial Luis Suarez goal, in which he handled the ball into the net, led to Liverpool winning at the one call stadium 2-1.
The Stags however, firstly need to get past League One side Oldham Athetlic, after the two sides drew 1-1 at Boundary Park yesterday.
If they do that, then they are on their way to Anfield to face a side currently in the top four of the Barclay's Premier League.
After being Mansfield last season, Liverpool were then beaten by Oldham themselves at Boundary Park, so either team throws up an interesting twist.
In the stand out tie of the round, Arsenal will play arch rivals Tottenham Hostspur at the Emirates.
Full draw:-
Barnsley v Hartlepool or Coventry
Yeovil v Leyton Orient
Liverpool v Oldham or Mansfield
Nottingham Forest v West Ham
Bristol City v Watford
Southend v Millwall
Middlesbrough v Hull
West Brom v Crystal Palace
Kidderminster v Peterborough
Doncaster v Stevenage
Stoke v Leicester
Southampton v Burnley
Newcastle v Cardiff
Rochdale v Leeds
Wigan v MK Dons
Charlton v Wrexham or Oxford United
Manchester United v Swansea
Port Vale v Plymouth
Norwich City v Fulham
Aston Villa v Sheffield United
Macclesfield v Sheffield Wednesday
Sunderland v Carlisle
Bolton v Blackpool
Blackburn v Manchester City
Everton v QPR
Brighton v Reading
Arsenal v Tottenham
Birmingham v Bristol Rovers or Crawley
Grimsby v Huddersfield
Ipswich v Preston
Derby v Chelsea
Bournemouth v Fleetwood or Burton
Ties to be played over the weekend of 4-5 January