"Of coure I am interested in them - it is our next game." he told the Mansfield CHAD website.
"It will be interesting to see if there is a reaction from the players. It will be a good test for us against quality Premiership players and it will be difficult. So let's see which of my players are up for it.
"I am hoping for a good atmosphere and a good performance. But as soon as it is over then I will be looking forward to playing Accrington Stanley at home on Saturday and I hope my players feel that way as well.
It has also emerged that both teams will have to change in portable cabins due to a burst pipe in the changing rooms, making them unavailable for the game.
Stags will be aiming to be the first side this season, to breach the Pompey defence, although it is doubtful the team Harry Redknapp sends out, will contain the defence which has acheived that remarkable record.
Shirtliff however is still looking to cause an upset, he continued "Harry is a good football man who likes his teams to play football. But we knocked his Southampton side out last season and I hope I can get another one up on him tomorrow night. It is a cup tie and anything can happen - you never know. We will give it a go."